English
norskBlar i forfatter "Bakland, Gunnstein"
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Certolizumab pegol, abatacept, tocilizumab or active conventional treatment in early rheumatoid arthritis: 48-week clinical and radiographic results of the investigator-initiated randomised controlled NORD-STAR trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-09)Background - The optimal first-line treatment in early rheumatoid arthritis (RA) is debated. We compared clinical and radiographic outcomes of active conventional therapy with each of three biological treatments with different modes of action.<p> <p>Methods - Investigator-initiated, randomised, blinded-assessor study. Patients with treatment-naïve early RA with moderate–severe disease activity ... -
Development of a feasible and responsive ultrasound inflammation score for rheumatoid arthritis through a data-driven approach
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-12-16)Objective: To develop and validate a responsive and feasible ultrasound inflammation score for rheumatoid arthritis (RA). Methods: We used data from cohorts of early RA (development) and established RA starting/switching biologic therapy (validation). 4 tendons and 36 joints were examined by a grey scale (GSUS) and power Doppler semiquantitative ultrasound (PDUS) scoring system (full score). ... -
Epidemiology and Outcome of Ankylosing Spondylitis in Northern Norway
(Doctoral thesis; Doktorgradsavhandling, 2012-05-29) -
Follow-Up of Patients With Axial Spondyloarthritis in Specialist Health Care With Remote Monitoring and Self-Monitoring Compared With Regular Face-to-Face Follow-Up Visits (the ReMonit Study): Protocol for a Randomized, Controlled Open-Label Noninferiority Trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-27)Background: Patients with chronic inflammatory joint diseases such as axial spondyloarthritis have traditionally received regular follow-up in specialist health care to maintain low disease activity. The follow-up has been organized as prescheduled face-to-face visits, which are time-consuming for both patients and health care professionals. Technology has enabled the remote monitoring of disease ... -
Lupus nephritis: low urinary DNase I levels reflect loss of renal DNase I and may be utilized as a biomarker of disease progression
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-21)Renal DNase I is lost in advanced stages of lupus nephritis. Here, we determined if loss of renal DNase I reflects a concurrent loss of urinary DNase I, and whether absence of urinary DNase I predicts disease progression. Mouse and human DNase I protein and DNase I endonuclease activity levels were determined by western blot, gel, and radial activity assays at different stages of the murine and human ... -
Mesenchymal stem cells and T cells in the formation of Tertiary Lymphoid Structures in Lupus Nephritis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-05-18)Tertiary lymphoid structures (TLS) develop in the kidneys of lupus-prone mice and systemic lupus erythematosus (SLE) patients with lupus nephritis (LN). Here we investigated the presence of mesenchymal stem cells (MSCs) in the development of TLS in murine LN, as well as the role of human MSCs as lymphoid tissue organizer (LTo) cells on the activation of CD4+ T cells from three groups of donors ... -
Ultrasound in management of rheumatoid arthritis: ARCTIC randomised controlled strategy trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-08-16)Objective: To determine whether a treatment strategy based on structured ultrasound assessment would lead to improved outcomes in rheumatoid arthritis, compared with a conventional strategy. <p>Design: Multicentre, open label, two arm, parallel group, randomised controlled strategy trial. <p>Setting: Ten rheumatology departments and one specialist centre in Norway, from September 2010 to ...
